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Oral Bioavailability Assessment
Basics and Strategies for Drug Discovery and Development
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Kitab haqqında
Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability – one of the most significant hurdles in drug discovery and development.<br /><br />• Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability<br />• Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development<br />• Explains how preclinical animal models – used in preclinical testing – and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development<br />• Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS)<br />• Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development
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Kitabın təsviri
Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability – one of the most significant hurdles in drug discovery and development.<br /><br />• Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability<br />• Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development<br />• Explains how preclinical animal models – used in preclinical testing – and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development<br />• Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS)<br />• Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development
Kitab Ayman F. El-Kattan «Oral Bioavailability Assessment» — saytda onlayn oxuyun. Şərh və rəylərinizi qeyd edin, sevimlilərinizi seçin.
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27 iyun 2018Həcm:
455 səh. ISBN:
9781118916940Ümumi ölçü:
9.3 МБSəhifələrin ümumi sayı:
455Naşir:
Müəllif hüququ sahibi:
John Wiley & Sons Limited
